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USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database


USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: P07355




USC-OGP 2-DE database:  P07355


P07355


General information about the entry
View entry in simple text format
Entry nameANXA2_HUMAN
Primary accession numberP07355
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Annexin A2; AltName: Full=Annexin II; AltName: Full=Annexin-2; AltName: Full=Calpactin I heavy chain; AltName: Full=Calpactin-1 heavy chain; AltName: Full=Chromobindin-8; AltName: Full=Lipocortin II; AltName: Full=Placental anticoagulant protein IV; Short=PAP-IV; AltName: Full=Protein I; AltName: Full=p36;.
Gene nameName=ANXA2
Synonyms=ANX2, ANX2L4, CAL1H, LPC2D
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10}
Homo sapiens (Human)
UVEAL_MELANOMA_3-10
  map experimental info
 
UVEAL_MELANOMA_3-10

MAP LOCATIONS:
pI=6.30; Mw=36464
pI=6.47; Mw=36158
pI=6.85; Mw=35254
pI=7.18; Mw=33988
pI=6.66; Mw=30628
pI=6.97; Mw=28628
pI=5.93; Mw=26725
pI=5.42; Mw=25688

Cross-references
UniProtKB/Swiss-ProtP07355; ANXA2_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameANXA2_HUMAN
Primary accession numberP07355
Secondary accession number(s) Q567R4 Q6N0B3 Q8TBV2 Q96DD5 Q9UDH8
Sequence was last modified on January 23, 2007 (version 2)
Annotations were last modified on March 15, 2017 (version 210)
Name and origin of the protein
DescriptionRecName: Full=Annexin A2; AltName: Full=Annexin II; AltName: Full=Annexin-2; AltName: Full=Calpactin I heavy chain; AltName: Full=Calpactin-1 heavy chain; AltName: Full=Chromobindin-8; AltName: Full=Lipocortin II; AltName: Full=Placental anticoagulant protein IV; Short=PAP-IV; AltName: Full=Protein I; AltName: Full=p36;
Gene nameName=ANXA2
Synonyms=ANX2, ANX2L4, CAL1H, LPC2D
Encoded onName=ANXA2; Synonyms=ANX2, ANX2L4, CAL1H, LPC2D
Keywords3D-structure; Acetylation; Alternative splicing; Annexin; Basement membrane; Calcium; Calcium/phospholipid-binding; Complete proteome; Direct protein sequencing; Extracellular matrix; Isopeptide bond; Phosphoprotein; Polymorphism; Reference proteome; Repeat; RNA-binding; Secreted; Ubl conjugation.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLD00017; BAA00013.1; -; mRNA
EMBLBT007432; AAP36100.1; -; mRNA
EMBLBX640598; CAE45704.1; -; mRNA
EMBLAC087385; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLBC001388; AAH01388.1; -; mRNA
EMBLBC009564; AAH09564.1; -; mRNA
EMBLBC015834; AAH15834.1; -; mRNA
EMBLBC016774; AAH16774.1; -; mRNA
EMBLBC021114; AAH21114.1; -; mRNA
EMBLBC023990; AAH23990.1; -; mRNA
EMBLBC052558; AAH52558.1; -; mRNA
EMBLBC052567; AAH52567.1; -; mRNA
EMBLBC066955; AAH66955.2; ALT_INIT; mRNA
EMBLBC068065; AAH68065.1; -; mRNA
EMBLBC093056; AAH93056.1; -; mRNA
CCDSCCDS10175.1; -. [P07355-1]; .
CCDSCCDS32256.1; -. [P07355-2]; .
PIRA23942; LUHU36; .
RefSeqNP_001002857.1; NM_001002857.1. [P07355-1]; .
RefSeqNP_001002858.1; NM_001002858.2. [P07355-2]; .
RefSeqNP_001129487.1; NM_001136015.2. [P07355-1]; .
RefSeqNP_004030.1; NM_004039.2. [P07355-1]; .
RefSeqXP_016877579.1; XM_017022090.1. [P07355-1]; .
RefSeqXP_016877580.1; XM_017022091.1. [P07355-1]; .
UniGeneHs.511605; -; .
PDB1W7B; X-ray; 1.52 A; A=1-339
PDB1XJL; X-ray; 2.59 A; A/B=21-339
PDB2HYU; X-ray; 1.86 A; A=32-339
PDB2HYV; X-ray; 1.42 A; A=32-339
PDB2HYW; X-ray; 2.10 A; A/B=32-339
PDB4DRW; X-ray; 3.50 A; A/B/C/D=2-16
PDB4FTG; X-ray; 2.51 A; C/D=2-16
PDB4HRH; X-ray; 3.00 A; A/B=2-16
PDBsum1W7B; -; .
PDBsum1XJL; -; .
PDBsum2HYU; -; .
PDBsum2HYV; -; .
PDBsum2HYW; -; .
PDBsum4DRW; -; .
PDBsum4FTG; -; .
PDBsum4HRH; -; .
ProteinModelPortalP07355; -; .
SMRP07355; -; .
BioGrid106799; 110; .
IntActP07355; 52; .
MINTMINT-1213203; -; .
STRING9606.ENSP00000346032; -; .
ChEMBLCHEMBL1764938; -; .
DrugBankDB00031; Tenecteplase; .
TCDB1.A.31.1.4; the annexin (annexin) family; .
iPTMnetP07355; -; .
PhosphoSitePlusP07355; -; .
SwissPalmP07355; -; .
BioMutaANXA2; -; .
DMDM113950; -; .
DOSAC-COBS-2DPAGEP07355; -; .
REPRODUCTION-2DPAGEIPI00455315; -; .
REPRODUCTION-2DPAGEP07355; -; .
UCD-2DPAGEP07355; -; .
EPDP07355; -; .
MaxQBP07355; -; .
PaxDbP07355; -; .
PeptideAtlasP07355; -; .
PRIDEP07355; -; .
TopDownProteomicsP07355-1; -. [P07355-1]; .
DNASU302; -; .
EnsemblENST00000332680; ENSP00000346032; ENSG00000182718. [P07355-2]; .
EnsemblENST00000396024; ENSP00000379342; ENSG00000182718. [P07355-1]; .
EnsemblENST00000421017; ENSP00000411352; ENSG00000182718. [P07355-1]; .
EnsemblENST00000451270; ENSP00000387545; ENSG00000182718. [P07355-1]; .
GeneID302; -; .
KEGGhsa:302; -; .
UCSCuc002agk.4; human. [P07355-1]; .
CTD302; -; .
DisGeNET302; -; .
GeneCardsANXA2; -; .
HGNCHGNC:537; ANXA2; .
HPACAB004311; -; .
MIM151740; gene; .
neXtProtNX_P07355; -; .
OpenTargetsENSG00000182718; -; .
PharmGKBPA24827; -; .
eggNOGKOG0819; Eukaryota; .
eggNOGENOG410XPUN; LUCA; .
GeneTreeENSGT00760000118972; -; .
HOGENOMHOG000158803; -; .
HOVERGENHBG061815; -; .
InParanoidP07355; -; .
KOK17092; -; .
OMAFIQQDTK; -; .
OrthoDBEOG091G0H6H; -; .
TreeFamTF105452; -; .
ReactomeR-HSA-445355; Smooth Muscle Contraction; .
ReactomeR-HSA-6798695; Neutrophil degranulation; .
ReactomeR-HSA-75205; Dissolution of Fibrin Clot; .
SIGNORP07355; -; .
ChiTaRSANXA2; human; .
EvolutionaryTraceP07355; -; .
GeneWikiAnnexin_A2; -; .
GenomeRNAi302; -; .
PROPR:P07355; -; .
ProteomesUP000005640; Chromosome 15; .
BgeeENSG00000182718; -; .
CleanExHS_ANXA2; -; .
ExpressionAtlasP07355; baseline and differential; .
GenevisibleP07355; HS; .
GOGO:0035578; C:azurophil granule lumen; TAS:Reactome; .
GOGO:0005604; C:basement membrane; IEA:UniProtKB-SubCell; .
GOGO:0016323; C:basolateral plasma membrane; ISS:BHF-UCL; .
GOGO:0005938; C:cell cortex; IEA:Ensembl; .
GOGO:0009986; C:cell surface; IDA:UniProtKB; .
GOGO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL; .
GOGO:0005829; C:cytosol; IEA:Ensembl; .
GOGO:0005769; C:early endosome; IEA:Ensembl; .
GOGO:0005768; C:endosome; IDA:UniProtKB; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0005576; C:extracellular region; TAS:Reactome; .
GOGO:0005615; C:extracellular space; IDA:UniProtKB; .
GOGO:0019897; C:extrinsic component of plasma membrane; IEA:Ensembl; .
GOGO:0031902; C:late endosome membrane; IDA:UniProtKB; .
GOGO:0005811; C:lipid particle; IDA:UniProtKB; .
GOGO:0005765; C:lysosomal membrane; IDA:UniProtKB; .
GOGO:0044354; C:macropinosome; IEA:Ensembl; .
GOGO:0042470; C:melanosome; IEA:UniProtKB-SubCell; .
GOGO:0016020; C:membrane; IDA:UniProtKB; .
GOGO:0030496; C:midbody; IDA:UniProtKB; .
GOGO:0035749; C:myelin sheath adaxonal region; IEA:Ensembl; .
GOGO:0005634; C:nucleus; IDA:UniProtKB; .
GOGO:1990667; C:PCSK9-AnxA2 complex; IDA:BHF-UCL; .
GOGO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl; .
GOGO:0005886; C:plasma membrane; IDA:BHF-UCL; .
GOGO:0001726; C:ruffle; IEA:Ensembl; .
GOGO:0042383; C:sarcolemma; IEA:Ensembl; .
GOGO:0043220; C:Schmidt-Lanterman incisure; IEA:Ensembl; .
GOGO:0031982; C:vesicle; IDA:UniProtKB; .
GOGO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL; .
GOGO:0005509; F:calcium ion binding; IEA:InterPro; .
GOGO:0005544; F:calcium-dependent phospholipid binding; IDA:UniProtKB; .
GOGO:0048306; F:calcium-dependent protein binding; IPI:AgBase; .
GOGO:0005546; F:phosphatidylinositol-4; 5-bisphosphate binding; IMP:UniProtKB
GOGO:0019834; F:phospholipase A2 inhibitor activity; IDA:UniProtKB; .
GOGO:0002020; F:protease binding; IPI:BHF-UCL; .
GOGO:0003723; F:RNA binding; IDA:UniProtKB; .
GOGO:0044548; F:S100 protein binding; IPI:UniProtKB; .
GOGO:0001525; P:angiogenesis; IEP:UniProtKB; .
GOGO:0007589; P:body fluid secretion; IEA:Ensembl; .
GOGO:0030199; P:collagen fibril organization; IEA:Ensembl; .
GOGO:0042730; P:fibrinolysis; IEA:Ensembl; .
GOGO:0006900; P:membrane budding; IMP:UniProtKB; .
GOGO:0001765; P:membrane raft assembly; IMP:UniProtKB; .
GOGO:0032804; P:negative regulation of low-density lipoprotein particle receptor catabolic process; IDA:BHF-UCL; .
GOGO:0043312; P:neutrophil degranulation; TAS:Reactome; .
GOGO:0036035; P:osteoclast development; IDA:UniProtKB; .
GOGO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl; .
GOGO:1905581; P:positive regulation of low-density lipoprotein particle clearance; IDA:BHF-UCL; .
GOGO:1905597; P:positive regulation of low-density lipoprotein particle receptor binding; IDA:BHF-UCL; .
GOGO:1905599; P:positive regulation of low-density lipoprotein receptor activity; IMP:BHF-UCL; .
GOGO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl; .
GOGO:0001921; P:positive regulation of receptor recycling; IDA:BHF-UCL; .
GOGO:1905602; P:positive regulation of receptor-mediated endocytosis involved in cholesterol transport; IDA:BHF-UCL; .
GOGO:0031340; P:positive regulation of vesicle fusion; IDA:UniProtKB; .
GOGO:0051290; P:protein heterotetramerization; IDA:UniProtKB; .
GOGO:0072661; P:protein targeting to plasma membrane; IEA:Ensembl; .
GOGO:0097066; P:response to thyroid hormone; IEA:Ensembl; .
Gene3D1.10.220.10; -; 4; .
InterProIPR001464; Annexin; .
InterProIPR018502; Annexin_repeat; .
InterProIPR018252; Annexin_repeat_CS; .
InterProIPR002389; ANX2; .
PANTHERPTHR10502:SF151; PTHR10502:SF151; 1; .
PfamPF00191; Annexin; 4; .
PRINTSPR00196; ANNEXIN; .
PRINTSPR00198; ANNEXINII; .
SMARTSM00335; ANX; 4; .
PROSITEPS00223; ANNEXIN; 4; .



USC-OGP 2-DE database image


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Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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