External data extracted from UniProtKB/Swiss-Prot |
Extracted from UniProtKB/Swiss-Prot, release: 0.0 |
Entry name | ANXA2_HUMAN |
Primary accession number | P07355 |
Secondary accession number(s) | Q567R4 Q6N0B3 Q8TBV2 Q96DD5 Q9UDH8 |
Sequence was last modified on | January 23, 2007 (version 2) |
Annotations were last modified on | March 15, 2017 (version 210) |
Name and origin of the protein |
Description | RecName: Full=Annexin A2; AltName: Full=Annexin II; AltName: Full=Annexin-2; AltName: Full=Calpactin I heavy chain; AltName: Full=Calpactin-1 heavy chain; AltName: Full=Chromobindin-8; AltName: Full=Lipocortin II; AltName: Full=Placental anticoagulant protein IV; Short=PAP-IV; AltName: Full=Protein I; AltName: Full=p36; |
Gene name | Name=ANXA2 Synonyms=ANX2, ANX2L4, CAL1H, LPC2D |
Encoded on | Name=ANXA2; Synonyms=ANX2, ANX2L4, CAL1H, LPC2D |
Keywords | 3D-structure; Acetylation; Alternative splicing; Annexin; Basement membrane; Calcium; Calcium/phospholipid-binding; Complete proteome; Direct protein sequencing; Extracellular matrix; Isopeptide bond; Phosphoprotein; Polymorphism; Reference proteome; Repeat; RNA-binding; Secreted; Ubl conjugation. |
Copyright |
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License |
Cross-references |
EMBL | D00017; BAA00013.1; -; mRNA |
EMBL | BT007432; AAP36100.1; -; mRNA |
EMBL | BX640598; CAE45704.1; -; mRNA |
EMBL | AC087385; -; NOT_ANNOTATED_CDS; Genomic_DNA |
EMBL | BC001388; AAH01388.1; -; mRNA |
EMBL | BC009564; AAH09564.1; -; mRNA |
EMBL | BC015834; AAH15834.1; -; mRNA |
EMBL | BC016774; AAH16774.1; -; mRNA |
EMBL | BC021114; AAH21114.1; -; mRNA |
EMBL | BC023990; AAH23990.1; -; mRNA |
EMBL | BC052558; AAH52558.1; -; mRNA |
EMBL | BC052567; AAH52567.1; -; mRNA |
EMBL | BC066955; AAH66955.2; ALT_INIT; mRNA |
EMBL | BC068065; AAH68065.1; -; mRNA |
EMBL | BC093056; AAH93056.1; -; mRNA |
CCDS | CCDS10175.1; -. [P07355-1]; . |
CCDS | CCDS32256.1; -. [P07355-2]; . |
PIR | A23942; LUHU36; . |
RefSeq | NP_001002857.1; NM_001002857.1. [P07355-1]; . |
RefSeq | NP_001002858.1; NM_001002858.2. [P07355-2]; . |
RefSeq | NP_001129487.1; NM_001136015.2. [P07355-1]; . |
RefSeq | NP_004030.1; NM_004039.2. [P07355-1]; . |
RefSeq | XP_016877579.1; XM_017022090.1. [P07355-1]; . |
RefSeq | XP_016877580.1; XM_017022091.1. [P07355-1]; . |
UniGene | Hs.511605; -; . |
PDB | 1W7B; X-ray; 1.52 A; A=1-339 |
PDB | 1XJL; X-ray; 2.59 A; A/B=21-339 |
PDB | 2HYU; X-ray; 1.86 A; A=32-339 |
PDB | 2HYV; X-ray; 1.42 A; A=32-339 |
PDB | 2HYW; X-ray; 2.10 A; A/B=32-339 |
PDB | 4DRW; X-ray; 3.50 A; A/B/C/D=2-16 |
PDB | 4FTG; X-ray; 2.51 A; C/D=2-16 |
PDB | 4HRH; X-ray; 3.00 A; A/B=2-16 |
PDBsum | 1W7B; -; . |
PDBsum | 1XJL; -; . |
PDBsum | 2HYU; -; . |
PDBsum | 2HYV; -; . |
PDBsum | 2HYW; -; . |
PDBsum | 4DRW; -; . |
PDBsum | 4FTG; -; . |
PDBsum | 4HRH; -; . |
ProteinModelPortal | P07355; -; . |
SMR | P07355; -; . |
BioGrid | 106799; 110; . |
IntAct | P07355; 52; . |
MINT | MINT-1213203; -; . |
STRING | 9606.ENSP00000346032; -; . |
ChEMBL | CHEMBL1764938; -; . |
DrugBank | DB00031; Tenecteplase; . |
TCDB | 1.A.31.1.4; the annexin (annexin) family; . |
iPTMnet | P07355; -; . |
PhosphoSitePlus | P07355; -; . |
SwissPalm | P07355; -; . |
BioMuta | ANXA2; -; . |
DMDM | 113950; -; . |
DOSAC-COBS-2DPAGE | P07355; -; . |
REPRODUCTION-2DPAGE | IPI00455315; -; . |
REPRODUCTION-2DPAGE | P07355; -; . |
UCD-2DPAGE | P07355; -; . |
EPD | P07355; -; . |
MaxQB | P07355; -; . |
PaxDb | P07355; -; . |
PeptideAtlas | P07355; -; . |
PRIDE | P07355; -; . |
TopDownProteomics | P07355-1; -. [P07355-1]; . |
DNASU | 302; -; . |
Ensembl | ENST00000332680; ENSP00000346032; ENSG00000182718. [P07355-2]; . |
Ensembl | ENST00000396024; ENSP00000379342; ENSG00000182718. [P07355-1]; . |
Ensembl | ENST00000421017; ENSP00000411352; ENSG00000182718. [P07355-1]; . |
Ensembl | ENST00000451270; ENSP00000387545; ENSG00000182718. [P07355-1]; . |
GeneID | 302; -; . |
KEGG | hsa:302; -; . |
UCSC | uc002agk.4; human. [P07355-1]; . |
CTD | 302; -; . |
DisGeNET | 302; -; . |
GeneCards | ANXA2; -; . |
HGNC | HGNC:537; ANXA2; . |
HPA | CAB004311; -; . |
MIM | 151740; gene; . |
neXtProt | NX_P07355; -; . |
OpenTargets | ENSG00000182718; -; . |
PharmGKB | PA24827; -; . |
eggNOG | KOG0819; Eukaryota; . |
eggNOG | ENOG410XPUN; LUCA; . |
GeneTree | ENSGT00760000118972; -; . |
HOGENOM | HOG000158803; -; . |
HOVERGEN | HBG061815; -; . |
InParanoid | P07355; -; . |
KO | K17092; -; . |
OMA | FIQQDTK; -; . |
OrthoDB | EOG091G0H6H; -; . |
TreeFam | TF105452; -; . |
Reactome | R-HSA-445355; Smooth Muscle Contraction; . |
Reactome | R-HSA-6798695; Neutrophil degranulation; . |
Reactome | R-HSA-75205; Dissolution of Fibrin Clot; . |
SIGNOR | P07355; -; . |
ChiTaRS | ANXA2; human; . |
EvolutionaryTrace | P07355; -; . |
GeneWiki | Annexin_A2; -; . |
GenomeRNAi | 302; -; . |
PRO | PR:P07355; -; . |
Proteomes | UP000005640; Chromosome 15; . |
Bgee | ENSG00000182718; -; . |
CleanEx | HS_ANXA2; -; . |
ExpressionAtlas | P07355; baseline and differential; . |
Genevisible | P07355; HS; . |
GO | GO:0035578; C:azurophil granule lumen; TAS:Reactome; . |
GO | GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell; . |
GO | GO:0016323; C:basolateral plasma membrane; ISS:BHF-UCL; . |
GO | GO:0005938; C:cell cortex; IEA:Ensembl; . |
GO | GO:0009986; C:cell surface; IDA:UniProtKB; . |
GO | GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL; . |
GO | GO:0005829; C:cytosol; IEA:Ensembl; . |
GO | GO:0005769; C:early endosome; IEA:Ensembl; . |
GO | GO:0005768; C:endosome; IDA:UniProtKB; . |
GO | GO:0070062; C:extracellular exosome; IDA:UniProtKB; . |
GO | GO:0005576; C:extracellular region; TAS:Reactome; . |
GO | GO:0005615; C:extracellular space; IDA:UniProtKB; . |
GO | GO:0019897; C:extrinsic component of plasma membrane; IEA:Ensembl; . |
GO | GO:0031902; C:late endosome membrane; IDA:UniProtKB; . |
GO | GO:0005811; C:lipid particle; IDA:UniProtKB; . |
GO | GO:0005765; C:lysosomal membrane; IDA:UniProtKB; . |
GO | GO:0044354; C:macropinosome; IEA:Ensembl; . |
GO | GO:0042470; C:melanosome; IEA:UniProtKB-SubCell; . |
GO | GO:0016020; C:membrane; IDA:UniProtKB; . |
GO | GO:0030496; C:midbody; IDA:UniProtKB; . |
GO | GO:0035749; C:myelin sheath adaxonal region; IEA:Ensembl; . |
GO | GO:0005634; C:nucleus; IDA:UniProtKB; . |
GO | GO:1990667; C:PCSK9-AnxA2 complex; IDA:BHF-UCL; . |
GO | GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl; . |
GO | GO:0005886; C:plasma membrane; IDA:BHF-UCL; . |
GO | GO:0001726; C:ruffle; IEA:Ensembl; . |
GO | GO:0042383; C:sarcolemma; IEA:Ensembl; . |
GO | GO:0043220; C:Schmidt-Lanterman incisure; IEA:Ensembl; . |
GO | GO:0031982; C:vesicle; IDA:UniProtKB; . |
GO | GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL; . |
GO | GO:0005509; F:calcium ion binding; IEA:InterPro; . |
GO | GO:0005544; F:calcium-dependent phospholipid binding; IDA:UniProtKB; . |
GO | GO:0048306; F:calcium-dependent protein binding; IPI:AgBase; . |
GO | GO:0005546; F:phosphatidylinositol-4; 5-bisphosphate binding; IMP:UniProtKB |
GO | GO:0019834; F:phospholipase A2 inhibitor activity; IDA:UniProtKB; . |
GO | GO:0002020; F:protease binding; IPI:BHF-UCL; . |
GO | GO:0003723; F:RNA binding; IDA:UniProtKB; . |
GO | GO:0044548; F:S100 protein binding; IPI:UniProtKB; . |
GO | GO:0001525; P:angiogenesis; IEP:UniProtKB; . |
GO | GO:0007589; P:body fluid secretion; IEA:Ensembl; . |
GO | GO:0030199; P:collagen fibril organization; IEA:Ensembl; . |
GO | GO:0042730; P:fibrinolysis; IEA:Ensembl; . |
GO | GO:0006900; P:membrane budding; IMP:UniProtKB; . |
GO | GO:0001765; P:membrane raft assembly; IMP:UniProtKB; . |
GO | GO:0032804; P:negative regulation of low-density lipoprotein particle receptor catabolic process; IDA:BHF-UCL; . |
GO | GO:0043312; P:neutrophil degranulation; TAS:Reactome; . |
GO | GO:0036035; P:osteoclast development; IDA:UniProtKB; . |
GO | GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl; . |
GO | GO:1905581; P:positive regulation of low-density lipoprotein particle clearance; IDA:BHF-UCL; . |
GO | GO:1905597; P:positive regulation of low-density lipoprotein particle receptor binding; IDA:BHF-UCL; . |
GO | GO:1905599; P:positive regulation of low-density lipoprotein receptor activity; IMP:BHF-UCL; . |
GO | GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl; . |
GO | GO:0001921; P:positive regulation of receptor recycling; IDA:BHF-UCL; . |
GO | GO:1905602; P:positive regulation of receptor-mediated endocytosis involved in cholesterol transport; IDA:BHF-UCL; . |
GO | GO:0031340; P:positive regulation of vesicle fusion; IDA:UniProtKB; . |
GO | GO:0051290; P:protein heterotetramerization; IDA:UniProtKB; . |
GO | GO:0072661; P:protein targeting to plasma membrane; IEA:Ensembl; . |
GO | GO:0097066; P:response to thyroid hormone; IEA:Ensembl; . |
Gene3D | 1.10.220.10; -; 4; . |
InterPro | IPR001464; Annexin; . |
InterPro | IPR018502; Annexin_repeat; . |
InterPro | IPR018252; Annexin_repeat_CS; . |
InterPro | IPR002389; ANX2; . |
PANTHER | PTHR10502:SF151; PTHR10502:SF151; 1; . |
Pfam | PF00191; Annexin; 4; . |
PRINTS | PR00196; ANNEXIN; . |
PRINTS | PR00198; ANNEXINII; . |
SMART | SM00335; ANX; 4; . |
PROSITE | PS00223; ANNEXIN; 4; . |